The injection of Platelet Rich Plasma (PRP) mesotherapy is a technique of aesthetic medicine to improve the quality of the skin by acting on the direct consequences of aging.
The principle of autologous cell regeneration
Platelet Rich Plasma Injections use the regenerative and healing properties of platelets. These have the ability to locally release growth factors, small molecules acting as true messengers to activate the initiation of skin regeneration mechanisms.
Plasma contains factors essential for cell survival such as nutrients, vitamins, hormones, minerals and proteins. Among the plasma proteins are the essential molecules for coagulation and the generation of a fibrin clot which serves as a guide for migration, differentiation and cell proliferation.
An injection of Platelet Rich Plasma is a treatment indicated for patients who want a rejuvenation and an embellishment of the skin of the face, décolleté, back and / or hands.
It allows to:
- Improve the texture, the density and the luminosity of the skin (decreasing of the brown spots related to UV as well as redness).
- Reduce wrinkles and fine lines, dark circles
- Improve the appearance of acne scars or post-traumatic scars
- Increase the synthesis or regeneration of elastic fibres of the skin, collagen
General information about the treatment
The medical device used for the entire treatment is subject to a certification of conformity for medical use in Europe and the United States. The medical device allows the preparation of Platelet Rich Plasma from the blood by centrifugation.
PRP is a plasma preparation (the liquid fraction of blood) in which platelets (the blood cells responsible for coagulation) have been concentrated.
This PRP is used as a source of growth factors, known to play a role of primary importance in the process of tissue regeneration. Thus, the injection of PRP into the skin makes it possible, in particular, to stimulate the microvasculature process and the formation of new collagen fibres, thus restoring a younger appearance to the treated surface (smoothed lines, unified complexion, etc.). .
PRP is prepared exclusively from the patient’s own blood; it is therefore a so-called autologous preparation, which avoids the risks of rejection or transmission of infectious diseases. This is usually referred to as Autologous Platelet Rich Plasma (or A-PRP) injections.
The course of treatment
The treatment usually takes place over a period of one month and consists of three injections of Platelet Rich Plasma at 21-28 days apart.
During a first visit, a diagnosis of the skin quality is established using the Visia system (only for the face) which makes it possible to analyse precisely and objectively the state of the skin on the basis of several criteria .
Before the operation, it is imperative that the area to be treated is cleansed and dry. Taking aspirin should be avoided during the 24 hours before the session.
The procedure consists firstly of collecting 8 ml of blood. This is centrifuged sterilely to obtain 4 to 5 ml of PRP.
The PRP obtained will be re-injected over the entire surface of the face, décolleté or back of the hands according to the so-called technique of “mesothérapic topping” (superficial injection into the dermis of small amounts of PRP using a thin needle).
In the next session, the treatment will be continued in the same mode.
At the end of the treatment period, 3 months after the last injection, a follow-up visit will be planned in order to evaluate the result and the possible need to set up a maintenance treatment.
It is recommended to carry out maintenance treatments every 3 to 6 months then every 6 to 12 months according to the quality of the skin, the age and the patient’s antecedents (important solar exposure, smoking). It should be known that these maintenance treatments can be performed by other methods of skin treatment (mesotherapy, peel, laser, etc.).
The treatment is performed by Dr Chokron, in 1 to 3 sessions, spaced a month or so, under no anaesthesia or only with EMLA cream.
Follow up and contraindications
Following an injection of Platelet Rich Plasma is usually simple.
A painful sensation can be felt during bites. It is variable according to the patients. A moisturising and soothing cream is routinely prescribed and administered after the session and should be applied for 48 hours.
The treated area is usually marked by papules that usually disappear between 3 and 12 hours. Some small bruises may sometimes be present on some stitches.
Since the PRP obtained is derived from the patient’s own blood, the risk of side effects is minimised and so far only mild inflammatory reactions with oedema and redness have been observed a few times in the hours following injection. These disappear gradually in the days that follow.
Other redactions may occur with certain medications (isotretinoin, Roaccutane). To avoid any risk, strong drug treatments in progress or started during treatment should be reported.
In addition, discomfort related to the blood test, such as bruises, can be noticed.
The use of PRP is contraindicated in patients with skin lesions that may be caused by abnormal cell proliferation processes. In case of doubt, your practitioner must carry out a preliminary diagnosis. The same is true if you have a blood disorder (e.g. thrombocytopenia) or an autoimmune disease.
As with all other subcutaneous injection treatments, taking antiaggregant (aspirin, Kardegic) concomitantly with the injection is contraindicated.
The intervention is also contraindicated when taking drugs promoting sensitivity to light or beta-carotene, such as certain antibiotics or antidepressants.
Since the effects of Platelet Rich Plasma on the foetus are not known, women who participate in treatment should use a reliable method of contraception throughout the course of treatment.